Several studies indicate that GPCR, seven-transmembrane receptors and a large diverse family of cell surface signaling receptors, are the most common targets in current pharmaceutical industry, and represent the largest and most versatile family of cell surface communicating molecules. Therefore, GPCRs are involved in many key cellular and physiological processes, such as sense of light, taste and smell, neurotransmission, metabolism, endocrine and exocrine secretion. GPCRs can be activated by a diverse array of ligands including neurotransmitters, chemokines as well as sensory stimuli.  In addition to the endogenous ligands, antibodies  can also bind to the GPCRs to activate or inhibit their activation. VHH is one of the most powerful antibody that can rise significantly used in the development of therapeutics marketing.

In caminnov, we have developped many GPCR libraries based on the immunization of our animals by HEK cells transfected with GPCRs DNA.

  • Tailored immunization campaigns.

  • Guaranteed in-frame VHH clones.

Libraries ready to use 

5-HT1A receptor

5-HT1C receptor

5-HT1D receptor

5-HT2A receptor

5-HT2C receptor

5-HT4 receptor

5-HT5A receptor

5-HT6 receptor

Cannabinoid receptors

CCR1

CX3CR1 receptor

CXCR1 receptor

CXCR6 receptor

GPR54

Muscarinic acetylcholine receptor M1 

Muscarinic acetylcholine receptor M3

Δ-opioid receptor

κ-opioid receptor

μ-opioid receptor

Libraries in progress

Alpha-1D adrenergic receptor

Alpha-1β adrenergic receptor

Alpha-2 adrenergic receptor

CCR2 receptor

CCR8 receptor

EP1 receptor

EP3 receptor

Gonadotropin-releasing hormone receptor

GPR37 receptor

Histamine H3 receptor

Neurotensin receptor

Neurotensin receptor 2

OPRL1 opioid related nociceptin receptor 1

Prostaglandin EP1 receptor